Assessment of Serum Enzymes Gamma Glutamyl Trasnferase, Aspartate Transaminase and Alanine Transaminase in Liver Diseases

Back Ground:Liver diseases are common disorders encountered in clinical practices. Investigations in liver diseases are used to detect hepatic abnormality, to measure its severity, to define it structural effect on the liver, to look for specific causes of liver diseases, assess prognosis and to evaluate therapy. Aim and Objectives:To study and compare the altered serum levels of enzymes GGT, AST and ALT in various liver diseases and also to assess their usefulness in differential diagnosis of liver diseases. Methods:The patients admitted to Chigateri General Hospital and Bapuji Hospital Davangere were selected for the present study. Total number of 124 subjects were chosen which include 50 controls and 74 cases of liver diseases. The liver diseases were further grouped into acute hepatitis, chronic hepatitis and cirrhosis of liver. Abbreviation: GGT-Gamma glutamyl transferase, ASTAspartate transaminase,ALT-Alanine transaminase. Results:The mean levels of GGT was increased in acute liver hepatitis, chronic hepatitis and cirrhosis of liver (non alcoholic and alcoholic) with P value highly significant p < 0.001 as compared to control subjects. The mean levels of AST and ALT were increased in acute hepatitis, chronic hepatitis and cirrhosis of liver (non alcoholic and alcoholic) with p value is highly significant p < 0.001 as compared to control subjects. Statistical significance is observed in non alcoholics and alcoholic cirrhosis for AST but no statistical significance found for ALT in non alcoholic and alcoholic cirrhosis and duration wise comparison in alcoholic cirrhosis. Conclusion:Liver function tests can be of value prognostically in screening for liver disease and are vital in monitoring of liver disease in response to treatment.